Some invincible enemies will be rerolled, while others (including most Grimace variants) are completely unaffected.( Horfs are classified as ground monsters by the D10). Flying monsters will only be rerolled into other flying monsters, and ground monsters can only be rerolled into ground monsters.Sealed doors open after 2 minutes, though there are situations that can prevent this failsafe from triggering.Jumping or flying monsters may become trapped behind rocks after being rerolled, and therefore become unbeatable. Using this item can cause some rooms to become impossible to clear.The D10 will not reroll permanently charmed enemies.The D10 will not reroll Bosses but can reroll monsters spawned by bosses.
Re-rolling a monster will replace it with an entirely new one from any floor, making it dangerous to use early on in the game (as Isaac could get monsters from Depths or later).Monster Replacement Tables Affected monsters